Background: From 2007 to 2009, the Netherlands experienced a major Q fever epidemic.Long-term serological follow-up of acute Q fever patients enabled the investigation of longitudinal antibody responses and estimating the click here onset of the seroresponse in individual patients.Methods: All available IgG and IgM phase I and II antibody measureme
Cyclin D1 regulates G1 progression.Its transcriptional regulation is well understood.However, the mechanism underlying cyclin D1 ubiquitination and its subsequent degradation is not yet clear.We report that cyclin D1 undergoes increased degradation in the cytoplasm during S phase in a variety of cancer cells.This is mediated by phosphorylation at T
The mammalian intestine harbors a complex microbial ecosystem that influences many aspects of host physiology.Exposure to specific microbes early in development affects host metabolism, immune function, and behavior across the lifespan.Just as the physiology of the developing organism undergoes a period of plasticity, the developing microbial ecosy
First Poles were sent to Siberia to an exile as early as the second half of the 18th century to be followed by the participants of the Napoleonic campaign of 1812.It is estimated that after the fall of the November Uprising (1831), about ten thousand young Poles were taken captive and deported to Siberia.Soon they were joined by those, especially f
The involvement of kyai be described in the domain of politics is interesting because in almost every general election, the involvement of kyai absolutely necessary as a tool to gain sound.As the development of the, involvement in the domain kyai in fact also not just limited to the role behind the screen, but perform as candidates deputy head of t